Experimental autoimmune encephalomyelitis (EAE) models of MS were established to test the efficacy of the CPT1 blocker, Etomoxir. Western Blotting was executed in order to test antibody response against brain proteins in EAE animal sera. Antigens recognized by autoantibodies were immunoprecipitated and analyzed by mass spectrometry with the purpose to identify these antigens, and thereby identifying a correlation between MS and brain antigens.

Major depressive disorder is a complex and common mental disease, for which the pathology has not been elucidated. The purpose of this study is to provide knowledge about the importance of mitochondrial dysfunction, dysregulated lipid metabolism and inflammation.

Multiple sclerosis (MS) is an inflammatory autoimmune disease in the central nervous system (CNS) characterized by demyelination, inflammatory plaques, oxidative stress and degradation of the blood-brain barrier (BBB)1,2. The etiology of MS is still not fully understood; however, different hypotheses involving infiltration of peripheral T cells activated by molecular mimicry or bystander activation, which triggers the immune system, have been proposed3.