Publications

Publications

CMSC Digging deeper into MS pathology
May 25, 2017

Experimental autoimmune encephalomyelitis (EAE) models of MS were established to test the efficacy of the CPT1 blocker, Etomoxir. Western Blotting was executed in order to test antibody response against brain proteins in EAE animal sera. Antigens recognized by autoantibodies were immunoprecipitated and analyzed by mass spectrometry with the purpose to identify these antigens, and thereby identifying a correlation between MS and brain antigens.

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Blocking of CPT1 reduces stress-induced depression
April 10, 2017

Major depressive disorder is a complex and common mental disease, for which the pathology has not been elucidated. The purpose of this study is to provide knowledge about the importance of mitochondrial dysfunction, dysregulated lipid metabolism and inflammation.

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The role of CPT1 in MS treatment
November 16, 2019

Multiple sclerosis (MS) is an inflammatory autoimmune disease in the central nervous system (CNS) characterized by demyelination, inflammatory plaques, oxidative stress and degradation of the blood-brain barrier (BBB)1,2. The etiology of MS is still not fully understood; however, different hypotheses involving infiltration of peripheral T cells activated by molecular mimicry or bystander activation, which triggers the immune system, have been proposed3.

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Aperiam harum

Articles about CPTone BIOTECT

CMSC Digging deeper into MS pathology
Experimental autoimmune encephalomyelitis (EAE) models of MS were established to test the efficacy of the CPT1 blocker, Etomoxir. Western Blotting was executed in order to test antibody response against brain proteins in EAE animal sera. Antigens recognized by autoantibodies were immunoprecipitated and analyzed by mass spectrometry with the purpose to identify these antigens, and thereby identifying a correlation between MS and brain antigens.
February 21, 2019
The role of CPT1 in MS treatment
Multiple sclerosis (MS) is an inflammatory autoimmune disease in the central nervous system (CNS) characterized by demyelination, inflammatory plaques, oxidative stress and degradation of the blood-brain barrier (BBB)1,2. The etiology of MS is still not fully understood; however, different hypotheses involving infiltration of peripheral T cells activated by molecular mimicry or bystander activation, which triggers the immune system, have been proposed3.
February 21, 2019
Blocking of CPT1 reduces stress-induced depression
Major depressive disorder is a complex and common mental disease, for which the pathology has not been elucidated. The purpose of this study is to provide knowledge about the importance of mitochondrial dysfunction, dysregulated lipid metabolism and inflammation.
February 21, 2019